Target Validation Package
What is it about
The Target Validation Package delivers in the shortest time possible a most accurate validation of target localization, binding and activation during drug development and optimization. It profits from the unique features of the 3D CoSeedis™ in chip technology forming physiologically relevant microtissues in statistically significant quantities.
Package
(One drug - one target)
- Choose a 3D CoSeedis™ tumor model
- 2D Cytotoxicity Assay – Validation of toxicity on chosen cell system
- Design of 3D disease model – Validation of custom tailored 3D cellular disease model
- 3D CoSeedis™ Cytotoxicity in chip Assay – Integration of 680 data points to determine highly accurate IC50 values
- 3D CoSeedis™ Drug Penetration Assay – Fast and accurate determination of drug binding and tissue penetration, cellular
target localization and interactions
Read-out and example data
- Model design and validation
- Transition 2D to 3D
- Physiological target cytotoxicity IC50
- Fast and accurate data on target interactions and tissue penetration
- Detailed customer defined report
Your benefits
- Time saving: 12 weeks to result
- Cost saving
- Micro-tissues of human cells
- 3R: animal free
- Cyclic Process
More Packages
- Rapid Drug Efficacy Check
- Drug safety
- Personalized efficacy
- Personalized toxicity target and off-target
- Pathway analysis