3D Laboratory Services
As a CRO our 3D Laboratory Services are specifically designed to support you in the set-up of your spheroid/organoid models, hence to run your preclinical studies in 3D. Or simply ask our experienced CRO laboratory to comprehensively assist you in the execution of the study evaluation.
Enlarge 3D CoSeedis service pipeline scheme
Predictive Disease Model Development
Profit from our cell culture experts, abc biopply’s international network of scientists, our connections to manufacturers and suppliers, and get your fully validated protocol along with all the required cell culture components for the spheroids/organoids of your choice. Or simply have our scientist instruct your personnel in 3D CoSeedis™ handling and spheroid/organoid analysis. Our flexibility is your benefit!
- Adapt and/or optimize protocols for the transfer of cells from 2D to 3D
- Validation and extension of existing protocols and/or applications for various disease models
- Models covering cell lines, primary cells and stem cells
- Design disease models to address cell-to-cell communication
- Design disease models to address organ-to-organ communication
- Design disease models to address complex multi-organ and multi-cellular disease models
3D CRO Laboratory Services
Assays, Characterization and Profiling of Study Results
- Growth monitoring
- Viability
- Live/dead
- Tumor Colony Forming Assays
- IHC
- IF
- ISH
- DNA/RNA/protein profiling
HTS/HCS Process Services
Our 3D CoSeedis™ technology has been specifically designed to feed your standardized High-Throughput and High-Content Screening processes with a mass-produced uniquely uniform and homogeneous spheroids/organoids.
On-site Services
- Implementation support for existing HTS/HCS processes using a fully validated interface between your established screening process and the 3D culture model
- Efficiency optimization of your standardized HTS/HCS process bases on 3D CoSeedis™ technology
- HCS downstream analysis allignment
In-house 3D Laboratory Services
- In-house high-content screening for various disease models and substrates
3D Genotox Assays
Based on our proprietary 3D CoSeedis™ technology we are offering a worldwide unique 3D genotoxicity assay for the genetic analysis of spheroids/organoids. In contrast to standard SCGE assays, our 3D Genotoxicity Assay assesses and integrates DNA-damage of entire spheroids/organoids. It consequently reflects genotoxic effects in a physiological 3-dimensional context.Together with our partner, 4D Lifetec, we are providing the 3D Genotoxicity Assay as a complimentary service for other CROs. However, you can also contact us to implement it directly into your own projects. Move your genotoxicity analyses together with us into a new universe of physiology.
3D Cell Culture Support & Conditioned Media Production
- Cell lines:
Establish fully validated or adapt existing protocols for your cell line of choice under 3D conditions. - Primary cells:
Establish fully validated or adapt existing protocols for primary cells of your choice. Protocols include procedures for cell isolation, enrichment and growth under 3D conditions. - Stem cells:
Establish fully validated or adapt existing protocols to grow and expand undifferentiated stem cells under 3D conditions. Develop validated procedures to differentiate stem cells in 3D into various cell lineages. - Conditioned Media:
Defined media (e.g. factors, proteins, extra cellular vesicles, etc.) on demand or as contract manufacturer harvested from customised 3D spheroids/organoids.
