Oncology Drug Discovery
Here you will find our service packages. Our team of experts offers customized solutions to support and realize the objectives of our customers' studies and researches.
Rapid Drug Efficacy Check
What is it about
The Rapid Drug Efficacy Check Package delivers in the shortest time possible a most accurate prediction of clinically relevant drug efficacy and dosages during hit validation, lead optimization and the preclinical test phase. It profits from the unique features of the 3D CoSeedis™ in chip technology forming physiologically relevant micro-tissues in statistically significant quantities.
Packages
(One drug - one target)
- Choose a 3D CoSeedis™ tumor model
- 2D Cytotoxicity Assay – Validation of toxicity on chosen cell system
- Design of 3D disease model – Validation of custom tailored 3D cellular disease model
- 3D CoSeedis™ Cytotoxicity in chip Assay – Integration of 680 data points to determine highly accurate IC50 values
- 3D CoSeedis™ Dose Response Assay – Most sensitive determination of drug effects over time to finetune dosage recommendation
Read-out and example data
- Model design and validation
- Transition 2D to 3D
- Physiological target cytotoxicity IC50
- Ex vivo dose response
- Validation of predictiveness with commercial alternative
- Detailed customer defined report
Your benefits
- Time saving: 10 weeks to result
- Cost saving
- Comparable predictiveness to mouse
- 3R: animal free
- Cyclic Process
More packages
- Drug safety
- Target Validation Package
- Personalized efficacy
- Personalized toxicity target and off-target
- Pathway analysis
Target Validation Package
What is it about
The Target Validation Package delivers in the shortest time possible a most accurate validation of target localization, binding and activation during drug development and optimization. It profits from the unique features of the 3D CoSeedis™ in chip technology forming physiologically relevant microtissues in statistically significant quantities.
Package
(One drug - one target)
- Choose a 3D CoSeedis™ tumor model
- 2D Cytotoxicity Assay – Validation of toxicity on chosen cell system
- Design of 3D disease model – Validation of custom tailored 3D cellular disease model
- 3D CoSeedis™ Cytotoxicity in chip Assay – Integration of 680 data points to determine highly accurate IC50 values
- 3D CoSeedis™ Drug Penetration Assay – Fast and accurate determination of drug binding and tissue penetration, cellular
- target localization and interactions
Read-out and example data
- Model design and validation
- Transition 2D to 3D
- Physiological target cytotoxicity IC50
- Fast and accurate data on target interactions and tissue penetration
- Detailed customer defined report
Your benefits
- Time saving: 12 weeks to result
- Cost saving
- Micro-tissues of human cells
- 3R: animal free
- Cyclic Process
More Packages
- Rapid Drug Efficacy Check
- Drug safety
- Personalized efficacy
- Personalized toxicity target and off-target
- Pathway analysis