3D CoSeedis™: a new in vitro approach to the COVID-19-related cytokine release syndrome
Are you harvesting extracellular vesicles from 3D cultures? 3D CoSeedis™ provides you with a new revolutionary way to harvest EVs.
Extracellular vesicles (EV), such as exosomes, have become the focus of many new therapeutic approaches, e.g. the prevention of uncontrolled cytokine release in COVID-19 patients (cytokine storm). Investigating different methods to harvest and isolate functional EVs has therefore become a top priority in establishing new treatment methods.
Recent findings have indicated that EVs derived from 3D spheroids are substantially different from vesicles harvested from 2D cultures. More important still, those studies indicated that EVs derived from 3D cultures are physiologically more relevant than their 2D counterparts.
In this context, 3D CoSeedis™was shown to revolutionise the production of physiological EVs in large quantities under reproducible, reliable and standardised conditions (Sara Rocha et al., Adv. Sci. 2018, 1800948; DOI: 10.1002/advs.201800948).
The 3D CoSeedis™ Chip Family provides the following advantages in EV research:
*** Grow up to 880 spheroids per single well of a 6-well plate
*** Harvest condition media from more than 16'000 spheroides per 24-well plate with the 3D CoSeedis™ Chip680
*** Keep spheroids in culture for up to 10 weeks for continued conditioned media production
Are you interested to try out the 3D CoSeedis™ platform for your own EV production? I am looking forward to supporting you in your set-up. Or would you like us to produce conditioned media from your cell type of choice for you? Please do not hesitate to contact me to discuss abc biopply’s range of conditioned media.
I am looking forward to hearing your feedback.
Marco Leu, PhD Sales & Operation abc biopply ag Direct Email / Phone +41 (0)79 834 95 56