In this study, the authors showed that the native micro environment generated in the 3D CoSeedis™ preclinical model not only helps to aggregate and propagate multiple myeloma (MM) cells ex vivo but consequently also leads to a much more accurate drug response outperforming alternative 3D technologies or 2D approaches. Moreover, the observed drug response to two classical compounds in MM treatment was a lot closer to the effects observed in patients and entirely opposite to the triggered behavior of cells in 2D.
“From a clinical viewpoint, this model may improve our ability to better predict later clinical success of preclinically active compounds to reduce time and financial expenses of drug discovery for MM at the earliest stage possible.”
For the webinar, co-author, Dr Andreas Thomsen (university of Freiburg, Germany) introduced the topic by describing the 3D CoSeedis™ 3D cell culture platform in some detail. He also emphasized the importance of having a reliable and physiologically accurate test system available for preclinical studies in order to reduce failure rates in later clinical studies.