Customised Service Manufacturing of Conditioned Media from 3D Spheroids/Organoids
Extracellular vesicles (EV) in general and exosomes in particular have become the focus of many clinical applications in recent years. Their possible involvement in the suppression of the COVID-19-related cytokine release syndrome (CRS) observed in patients with fatal disease progression has evolved into a prominent area of interest in the current pandemic. However, further preclinical studies to investigate the function of EVs in CRS suppression will be required to understand their therapeutic value in order to release them for the treatment of patients. Generally, investigating EVs requires a cellular source that produces physiologically relevant vesicles in reproducible qualities and quantities.
Recent studies (Rocha et al., 2018, DOI: 10.1002/advs.201800948) have shown how important it is to harvest EVs from conditioned media generated by 3D spheroids/organoids. Furthermore, Rocha and co-authors have shown the advantages of 3D CoSeedis™ in the generation of conditioned media under standardised and highly reproducible conditions.
Generally, investigating EVs requires a cellular source that produces physiologically relevant vesicles in reproducible qualities and quantities.
Customized conditioned media production
abc biopply produces customised and standardised conditioned media from 3D organoids/spheroids according to your requirements. Our manufacturing service includes:
All spheroids/organoids are generated in 3D CoSeedis™ chips
Free choice of cell type for spheroid/organoid formation