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Customised Service Manufacturing of Conditioned Media from 3D Spheroids/Organoids

Extracellular vesicles (EV) in general and exosomes in particular have become the focus of many clinical applications in recent years. Their possible involvement in the suppression of the COVID-19-related cytokine release syndrome (CRS) observed in patients with fatal disease progression has evolved into a prominent area of interest in the current pandemic. However, further preclinical studies to investigate the function of EVs in CRS suppression will be required to understand their therapeutic value in order to release them for the treatment of patients.
Generally, investigating EVs requires a cellular source that produces physiologically relevant vesicles in reproducible qualities and quantities.

Recent studies (Rocha et al., 2018, DOI: 10.1002/advs.201800948) have shown how important it is to harvest EVs from conditioned media generated by 3D spheroids/organoids. Furthermore, Rocha and co-authors have shown the advantages of 3D CoSeedis™ in the generation of conditioned media under standardised and highly reproducible conditions.
 
Generally, investigating EVs requires a cellular source that produces physiologically relevant vesicles in reproducible qualities and quantities.
Customized conditioned media production

abc biopply produces customised and standardised conditioned media from 3D organoids/spheroids according to your requirements. Our manufacturing service includes:
  • All spheroids/organoids are generated in 3D CoSeedis™ chips
  • Free choice of cell type for spheroid/organoid formation
  • Chose from:
    - Cell lines
    - Primary cells
    - Stem cells
    - iPS
    - complex cell systems (consisting of multiple cell types)
  • Flexible batch sizes: small to medium quantities possible
  • All manufacturing processes are customised and mile stone orientated
3D CoSeedis™ guaranties:
  • Large quantities of homogenous and uniform spheroids/organoids
     
  • Consequently, highly homogenous conditioned media production enriched in EVs
     
  • Unique features of 3D CoSeedis™ allow the collection of conditioned media from cells that are difficult to grow under 3D-conditions
-> LEARN MORE ABOUT THE 3D COSEEDIS™ TECHNOLOGY
Are you interested to get to know more about abc biopply’s contract manufacturing program of conditioned media? Please do not hesitate to contact me for further details and price requests.
 
I am looking forward to talking to you.

   Best regards

   Marco Leu, PhD
   Sales & Operation
   abc biopply ag
   Direct Email / Phone +41 (0)79 834 95 56
 

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