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How 3D CoSeedis™ creates physiologically relevant 3D micro-tumours:
- Proprietary chip design ensures the formation of micro-tumours with cells that otherwise resist 3D aggregation with alternative technologies, namely ULA plates, hanging drop, and liquid overlay assays.
- Fully diffusion permeable chip matrices allow the exchange of molecules between cells and spheroids. These molecules include oxygen, salts, proteins, and sugars. The design of 3D CoSeedis™ therefore allows the generation of tissue specific environments relevant for proper micro-tumour formation.
- The unique distance co-culture technology further allows the integration of tissue specific feeder cells that help to create the appropriate cellular neighbourhood for tumour formation.
- 3D cell aggregation in 3D CoSeedis™ leads to highly compact micro-tumours similar to what has been described in vivo. Tumour compactness is essential when assessing drug or antibody penetration of target tissues and also plays a major role in NK cell invasion of tumour tissues. 3D CoSeedis™ outperforms all other 3D technologies in this respect - no other 3D platform, e.g. ULA plates, has been able to mimic such a behaviour of 3D micro-tumours in vivo.
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