PART 2: Communication over long distances between 3D cell cultures (organ-to-organ communication)
The communication between multiple 3D structures. A brief introduction to highly efficient and predictive disease modelling with 3D CoSeedis™. PART 2
In part 1 of this series, abc biopply presented the 3D CoSeedis™ platform as a new and revolutionary way to mimic complex, yet more predictive, disease models, for example for compound testing. In part 2, we would like to introduce a novel and fascinating new aspect of the 3D CoSeedis™ distance co-culture application. In this approach we mimic organ-to-organ communication via multiples of 3D CoSeedis™ chips or combinations of hydrogels and 3D CoSeedis™ chips. Despite the relative complexity of such systems, with 3D CoSeedis™ they are easy to handle and show the following benefits:
Easy setup
Easy to manipulate and handle
Standardised
Seamless fit to downstream proccesses
Reliable and reproducible readouts
Includes large quantities of organoids/spheroids for statistical relevance
PART 2: Communication over long distances between 3D cell cultures (organ-to-organ communication)
Two 3D CoSeedis™ chips:
Two 3D CoSeedis™ chips can be stacked on top of each other (“sandwich”). By diffusion through the media and the matrix of the 3D CoSeedis™chips, the 3D cultures can exchange informative agents and therefore influence each other.
3D CoSeedis™ faces hydrogel:
A 3D CoSeedis™ chip with, for example, conical 3D cultures is sitting on top of a hydrogel layer containing spheroids. By diffusion, both 3D culture types are able to exchange information and consequently communicate with each other.
Key features:
Mimics long range communication between 3D cell cultures that do not directly touch each other => organ-to-organ communication
Individual 3D CoSeedis™ chips can be separated again for detailed analysis
3D cultures from 3D CoSeedis™ can be harvested for downstream processes
Despite mimicking complex communication processes, the setup is simple, robust, reproducible and reliable
With the modular setup of 3D CoSeedis™,complex disease modelling becomes assessable to analysis, hence a lot more predictive. Are you interested to get to know more? Keep following us for PART 3 of this interesting series or contact me to discuss the various areas in which 3D CoSeedis™ can be applied to investigate cell communication. I am looking forward to hearing your feedback.
