PART 2: Communication over long distances between 3D cell cultures (organ-to-organ communication)

The communication between
multiple 3D structures.

A brief introduction to highly efficient and predictive disease modelling with 3D CoSeedis™.
In part 1 of this series, abc biopply presented the 3D CoSeedis™ platform as a new and revolutionary way to mimic complex, yet more predictive, disease models, for example for compound testing.
In part 2, we would like to introduce a novel and fascinating new aspect of the 3D CoSeedis™ distance co-culture application. In this approach we mimic organ-to-organ communication via multiples of 3D CoSeedis™ chips or combinations of hydrogels and 3D CoSeedis™ chips.
Despite the relative complexity of such systems, with 3D CoSeedis™ they are easy to handle and show the following benefits:
  • Easy setup
  • Easy to manipulate and handle
  • Standardised
  • Seamless fit to downstream proccesses
  • Reliable and reproducible readouts
  • Includes large quantities of organoids/spheroids for statistical relevance
Communication over long distances between
3D cell cultures (organ-to-organ communication)

Two 3D CoSeedis™ chips:

Two 3D CoSeedis™ chips can be stacked on top of each other (“sandwich”).
By diffusion through the media and the matrix of the 3D CoSeedis™chips, the
3D cultures can exchange informative agents and therefore influence each other.

3D CoSeedis™ faces hydrogel:

A 3D CoSeedis™ chip with, for example, conical 3D cultures is sitting on top of a hydrogel layer containing spheroids. By diffusion, both 3D culture types are able to exchange information and consequently communicate with each other.

Key features:

  • Mimics long range communication between 3D cell cultures that do not directly touch each other => organ-to-organ communication
  • Individual 3D CoSeedis™ chips can be separated again for detailed analysis
  • 3D cultures from 3D CoSeedis™ can be harvested for downstream processes
  • Despite mimicking complex communication processes, the setup is simple, robust, reproducible and reliable
With the modular setup of 3D CoSeedis™, complex disease modelling becomes assessable to analysis, hence a lot more predictive.
Are you interested to get to know more? Keep following us for PART 3 of this interesting series or contact me to discuss the various areas in which
3D CoSeedis™ can be applied to investigate cell communication. I am looking forward to hearing your feedback.

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