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PART 3: Communication between multiple 3D structures

 
Communication between multiple 3D structures.
A brief introduction to highly efficient and predictive disease modelling with 3D CoSeedis™.
PART 3
In the last part of this series, we would like to combine the different methods by which 3D CoSeedis™ enables cell-to-cell and organ-to-organ communication that we presented in the previous 2 newsletters.
To do so, opens the door to an amazing complexity of what can be mimicked accurately in in vitro cell culture models with the help of 3D CoSeedis™. Yet, the setup of those models remains easy to handle, reproducible and, consequently and most importantly, predictive.

In the disease model we present in this newsletter, we combine:
  • 3D CoSeedis™ 3D conical aggregates with contact feeders
  • 3D CoSeedis™ 3D conical aggregates w/o feeders
  • Distance co-cultured feeders in 2D
  • Suspension cells
  • And a biological agent (e.g. drug compound, infections particle, else).
PART 3:
Predictive complex disease modelling
with 3D CoSeedis™
Complex cell-to-cell and organ-to-organ communication model to investigate systemic diseases. Note: the individual 3D structure can be combined at leisure to come up with a model that reflects best the situation in vivo.

In such a setup, it is possible to monitor the interaction and effect of:
  • Cells in direct contact with each other (e.g. intra-organic communication)
  • Cells from different organic origin (e.g. inter-organic communication)
  • Suspension cells with organs of different origin (e.g. blood cells)
  • And the response or reaction of the system to biologically active agents such as drug compounds, infectious particles, toxins, etc.

Despite the achieved complexity, the individual components and cells of the system can easily be analysed since the setup is all modular and can be separated for in-depth analysis via:
  • Immunohistochemistry
  • Immunofluorescence
  • Protein/DNA/RNA profiling
  • Catabolite content in medium
  • In situ hybridisation
  • Whole-mount staining methods
  • Volumetric analysis
  • And many more….
I am looking forward to continuing the discussion on complex and predictive disease modelling with 3D CoSeedis™ with you. Besides, abc biopply can also supply you with peripheral and complementary products, e.g.
  • Primary cells
  • Stem cells
  • Speciality media and supplements
  • Standardized enzyme for cell isolations
  • ECM coatings, components and solutions
  • Antibodies for marker indentification
  • Reference tissues and tissue extractions
to build up the disease model of your interest. Contact me to get to know more and for a comprehensive and competitive quote.

   Best regards

   Marco Leu, PhD
   Sales & Operation
   abc biopply ag
   Direct Email / Phone +41 (0)79 834 95 56
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