The 3D CoSeedis in chip communication technology™ defines an ideal tool to address drug safety and off-target toxicity with an unprecedented high accuracy. Mimicking physiological conditions in liver micro-tissues is particularly important to reliably assess potential toxic responses and to consequently define a non-toxic dosage window for downstream in vivo studies.
The 3D CoSeedis in chip communication technology™ allows the assembly of liver micro-tissues derived from cell line as well as from primary liver extracts. It therefore provides highest flexibility to address both, direct drug response rates (on-target) as well as drug safety assessments. Furthermore, it constitutes a nice model to investigate drug metabolism and break down.